Paho-physiologocal study for moyamoya disease : proteomix and neuroimaging analysis

我们对烟雾病的动脉病理生理进行了研究。我们评估了16名MMD患者、8名动脉粥样硬化性大脑中动脉狭窄患者和27名对照组的3D-CISS MRI研究。比较3组的颅内动脉外径，MMD组颈内动脉和大脑中动脉(ICA，M1)外径明显小于其他两组(P<0.05)。此外，颈内动脉外径与数字减影血管造影术评估的内管狭窄程度的进展无关。我们的3D-Ciss MRI文献首次报道，在MMD患者中，颈内动脉和M1的外径减小先于这些血管的内侧狭窄改变的减小。我们认为，ICA和M1的改变先于内部病理性狭窄的表现，并可能构成MMD进展的第一步。

We studied the arterial pathophysiology of moyamoya disease. We evaluated 3D-CISS MRI studies of 16 patients with MMD, 8 with atherosclerotic middle cerebral artery stenosis, and 27 control subjects. We compared the outside diameter of the intracranial arteries in these 3 groups.The outside diameter of the internal carotid- and the middle cerebral artery (ICA, M1) in the MMD group was significantly smaller than in the other 2 groups (p < 0.05). Furthermore, the outside diameter was unrelated to the progression of internal canal stenosis grade evaluated from digital subtraction angiography.Ours is the first 3D-CISS MRI documentation that in MMD patients, a decrease in the outer diameter of the ICA and M1 precedes the decrease in the inside stenotic change of these vessels. We suggest that changes in the ICA and M1 precede the manifestation of interior pathologial stenosis and may constitute the first step in MMD progression.