A treatment strategy for the gastrointestinal development of extremely premature infants by administration of micelles derived from pulmonary surfactants and the vernix caseosa

制备了牛肺表面活性剂和猪皮脂配合物（STA胶束溶液），并制备了与肺表面活性剂胶束形态相似的荧光金胶体脂质体。将STA胶束溶液和荧光金胶体脂质体连续注入孕兔羊水中。持续给药STA胶束溶液可能局部影响兔胎儿肠道形态和脂质吸收，从而保护肠细胞免受手术干预造成的损伤。我们还重点研究了坏死性小肠结肠炎（NEC）新生大鼠模型。STA胶束溶液通过干预凋亡通路减轻了NEC的严重程度。我们的研究旨在通过关注胎儿和新生儿环境中胶束的存在，建立一种确保极早产儿胃肠道发育的治疗策略。

We prepared bovine pulmonary surfactant and vernix caseosa complexes (STA micelle solution), and fluorescently gold colloid liposomes with morphology similar to that of pulmonary surfactant micelles. STA micelle solution and fluorescently gold colloid liposomes were then continuously infused into the amniotic fluid of pregnant rabbits. The continuous administration of STA micelle solution might locally influence the intestinal morphology and lipid absorption of the rabbit fetus, thus protecting the enterocytes from damage due to surgical intervention. We also focused on a necrotizing enterocolitis (NEC) newborn rat model. STA micelle solution reduced the severity of NEC by intervening in the apoptotic pathway. Our study is aiming to establish a treatment strategy to ensure the gastrointestinal development of extremely premature infants, by focusing on the presence of micelles in the environment of fetuses and neonates.