Expression and Bio-function of Sugar chains in uterine endometrial adenocarcinoma, cervical carcinoma and uterine endometrium

细胞膜上的糖链参与了各种细胞的相互识别和细胞分化，并且糖链的结构随着肿瘤的发生而改变。 在本研究中，我们已经阐明了将磺基转移酶基因转染到子宫内膜癌细胞中改变了细胞特性，例如细胞形态和对胰蛋白酶处理的反应，并且所有的子宫颈癌细胞都表达GM2神经节苷脂，并且对紫杉醇耐药的卵巢癌细胞强烈表达Gb3Cer和神经节苷脂，通过对卵巢癌患者和健康妇女血清中糖肽的质谱分析，发现了一种新的卵巢癌生物标志物。

Carbohydrate chains on cell membranes contributes to the mutal recognition of various cells and cell differentiation, and the structure of carbohydrate chains changes with oncogenesis. In this study, we have clarified that the transfection of sulfotransferase genes to endometrial cancer cells changes the cell characters such as cell morphology and response to the trypsin treatment, and that all the uterine cervical cancer cells express GM2 ganglioside, and that ovarian cancer cells resistant to Paclitaxel strongly express Gb3Cer and ganglioside, and that with analysis of glycopeptides in serum of ovarian cancer patients and healthy women by mass spectrometer, a new biomarker for ovarian cancers was found.