Parameters of oral environment for perioperative patients of lung cancer based on two dimensional analysis of breath gasses

对肺癌围手术期患者在口腔护理前、术后、术前、术后床边呼出气体、口腔空气和唾液进行气体分析。术前、术后分别测定保护性反射(咳嗽、吞咽反射)。对于没有术后肺炎的患者，术前口腔护理增加了唾液链球菌在厌氧条件下的比例，通常被称为健康相关菌。口腔护理还减少了唾液中的细菌总数，并减少了恶臭气体。术后丙酮浓度升高，CRP迅速升高，提示床边非侵入性测定挥发性硫化物和挥发性有机化合物可能反映了肺癌围手术期口腔环境和一般炎症状态。

We analyzed gasses from exhaled and mouth air and saliva of perioperative patients of lung cancer at bedside before oral care, after oral care before operation, and after operation. Protective reflexes (cough and swallowing reflex) were also measured before and after operation. As for patients without postoperative pneumonia, oral care before operation increased ratio of salivary streptococci, usually known as healthy-associated bacteria, in anaerobic condition. Oral care also decreased total number of bacteria in saliva and decreased malodorous gasses. Acetone concentration increased after operation with rapid increase of CRP.This study suggests possibility that non-invasive measuring volatile sulfide compounds and volatile organic compounds at bedside indicate oral environments and general inflammatory conditions of perioperative lung cancer.