The basic research on oral environment of community-acquired pneumonia prevention in a local community elderly

本研究通过对一名正常成人和一名社区老年人的唾液蛋白浓度（分泌型免疫球蛋白A：sIgA;乳铁蛋白：LF;表皮生长因子：EGF）的测定，阐明了唾液蛋白浓度对口腔内细菌和携带细菌的肺炎链球菌的控制作用，为社区获得性肺炎的预防提供基础研究。并分析了唾液蛋白浓度与年龄、肺炎链球菌带菌情况及肺炎球菌接种情况的关系，发现成年组肺炎链球菌带菌率最高（55.6%）。成人组sIgA、LF、EGF浓度高于老年组和老年期。未发现肺炎球菌疫苗接种因子与sIgA浓度之间存在关联。老年人中未携带者和携带者sIgA、LF（老年期）、EGF浓度均高于携带者。

We clarified the saliva protein concentrations (secretory immunoglobulin A: sIgA; lactoferrin: LF; epidermal growth factor: EGF) which controlled to intraoral bacteria, and Streptococcus pneumoniae carrying germs for a normal adults and a local community elderly, as a basic research for the community-acquired pneumonia prevention. And we examined the association of a concentration of saliva protein with age, Streptococcus pneumoniae carrying germs and pneumococcus vaccination.An adult group was the highest in the ratio of Streptococcus pneumoniae carriers (55.6%). The concentrations of sIgA, LF, EGF were higher in the adult group than the older adult and old-old groups. No association was found between the pneumococcus vaccination factor and the sIgA concentration. As for non-carrying and carrying group among the elderly, non-carrying were higher than those carrying in sIgA, LF (old-old group), and EGF concentration.