Establishment of suitable diet plan focusing on liver fat for prevention of lifestyle-related disease and health promotion

本研究旨在为日本肥胖代谢综合征(METS)患者制定合适的饮食计划，以预防与生活方式相关的疾病，促进健康。为了评价饮食对体脂组成的影响，我们用700-800层螺旋CT行1H-MRS和全腹部CT扫描，分别定量测量肝脏脂肪含量和腹部内脏脂肪体积和皮下脂肪体积。结果表明，总能量28千卡/理想体重公斤，碳水化合物50~55%，脂肪25~30%，蛋白质15~20%的营养平衡，可使肝脏脂肪减少56%，内脏脂肪体积和腹部皮下脂肪体积平均减少22%，并改善血压、血糖和血脂等临床指标。此外，在整个为期一年的饮食期间，没有观察到八号身体的退出或反弹的情况。因此，这一饮食计划是推荐给患有肥胖症和METS的日本人的。

We investigated to establish suitable diet plan for Japanese obese subjects with metabolic syndrome (METS) to prevent lifestyle-related disease and contribute to health promotion. To evaluate effect of diet on body fat composition, we performed 1H-MRS and whole abdominal CT-scanning by 700-800 slices for quantitative measurement of liver fat content and abdominal visceral and subcutaneous fat volume, respectively. In results, total energy of 28 kcal/ideal body weight kg, and nutritional balance of carbohydrate 50-55 %, fat 25-30 %, and protein 15-20 % was reduced liver fat by 56 % and visceral fat volume and abdominal subcutaneous fat volume equally by 22 %, and improved clinical parameters such as blood pressure, plasma glucose and lipids, or HOMA-R. Furthermore, throughout this diet period for 1 year, no case of drop out or showing rebound of body eight was observed. Consequently, this diet plan is recommendable to Japanese subjects with obese and METS subjects.