Synthesis and Application of Unnatural Chiral Amino acids and Peptides

为了开发氨基酸化学的新领域，我们致力于具有动态手性或硅立体中心的手性氨基酸和多肽的合成。我们完成了具有正环膦骨架的动态平面手性氨基酸和多肽的合成。此外，我们成功地开发了手性烯基氢化硅烷的催化对映体选择性方法，这是具有硅立体中心的手性氨基酸的潜在手性构建块。

To develop the novel field of amino acid chemistry, we focused on the synthesis of chiral amino acids and peptides having dynamic chirality or a silicon stereocenter. We accomplished the synthesis of dynamic planar chiral amino acids and peptides having an orthocyclophane skeleton. Furthermore, we successfully developed a catalytic enantioselective approach to chiral alkenylhydrosilanes, which are potential chiral building blocks for chiral amino acids having a silicon stereocenter.