The role for fatty acid β-oxidation system in retinal Muller cell

通过生物学和形态学研究，对视网膜米勒细胞和视网膜神经节细胞的营养代谢，特别是脂肪酸β氧化系统进行了初步探讨。免疫荧光显微镜显示所有酶均存在于培养的视网膜Muller细胞中。由于视网膜神经节细胞培养体系难以建立，原代培养的海马神经元和星形胶质细胞被交替尝试。与肝组织相比，成熟神经元含有相对较少的脂肪酸β氧化酶。本研究结果有助于阐明视网膜的能量产生系统。

The nutrient metabolism of Muller cell and retinal ganglion cell of theretina, fatty acid β-oxidation system in particular, was attempted by biological and morphologicalstudies. All the enzymes examined were shown to be present in the cultured retinal Muller cell byimmunofluorescent microscopy. Because of difficulty with establishment of the culture system ofretinal ganglion cells, primary cultured hippocampal neuron and astrocytes were attemptedalternatively. Mature neurons contain relatively small amount of fatty acid β-oxidation enzymes asthat of the liver tissue. The present results are helpful in elucidating the energy production systemin the retina.