Mechanoregulation of periodontal ligament homeostasis by primary cilia

机械应力对牙周膜组织的动态平衡有重要作用。在这项研究中，我们探讨初级纤毛的分布和机械反应，一个可能的机械传感器在PDL。PDL可见抗乙酰化微管蛋白阳性的初级纤毛。初级纤毛优先分布于牙周膜侧。过度的眼负荷条件下，初级纤毛的数量增加。这些结果表明初级纤毛的优先分布可能有助于PDL的位点特异性机械反应。

It is evident that mechanical stress contributes the tissue homeostasis of periodontal ligament (PDL). In this study, we explore the distribution and mechanoresponse of primary cilia, a possible mechanosensor in PDL. The anti-acetylated tubulin positive primary cilia were detected in PDL. The primary cilia was preferentially distributed at the cementum side of PDL. The excessive occlulsal loading condition increased the number of primary cilia. These results indicate that the preferential distribution of primary cilia may contribute the site specific mechanoresponse of the PDL.