Biomechanical analyses and preventing stress shielding of titaniumalloy's implant with a low Young's modulus.

Ti29Nb13Ta4.6Zr合金（TNTZ）作为生物材料具有杨氏模量低、细胞毒性低、无过敏原等优点。然而，目前尚不清楚TNTZ是否可以达到足够的骨整合，以用作牙科种植体。射频（RF）磁控溅射对TNTZ植入物表面改性的有利效果也不清楚。我研究了TNTZ种植体在体内的生物力学行为，使用四种类型的圆柱形种植体：纯钛，TNTZ，纯钛和TNTZ包覆磷酸钙（CaP）。植入大鼠股骨，并在不同时间间隔后对股骨进行生物力学分析。结果表明，TNTZ种植体可以达到与纯钛相似的骨整合效果，并且射频磁控溅射对表面进行CaP修饰可以改善骨整合效果。

Ti29Nb13Ta4.6Zr alloy (TNTZ) has excellent advantages as a biomaterial, such as low Young's modulus and cytotoxicity, and the absence of allergens. However, it is unclear whether TNTZ can achieve sufficient osseointegration to be used as a dental implant. The advantageous effect of surface modification of TNTZ implants by radiofrequency (RF) magnetron sputtering is also unclear. I investigated the biomechanical behaviors of TNTZ implants in vivo, using cylindrical implants of four types: pure Ti, TNTZ, and pure Ti and TNTZ coated with calcium phosphate (CaP). The implants were inserted in rat femurs, and the femurs were subjected to biomechanical analyses after various time intervals. The results suggest that TNTZ implants can achieve osseointegration similar to that of pure Ti, and that surface modification with CaP by RF magnetron sputtering improves osseointegration.