Development of the method promotingwound healing and inhibiting scar formation via targeting Smad3 protein phosphorylation

Cleft Palate患者经常受到严重的增长影响和狭窄的牙科手术后的外科关闭，导致缺陷的严重性。这被认为是一个疤痕的后果，它将形成一个在Palatal Wound治疗期间。Smad 3是其中一个被认为是TGF的成员之一--信号路径，它在受伤的平板中展示了明显加速的伤口愈合。在这一研究中，我们调查了Smad 3基因表达在伤口修复中的抑制作用，作为一个结果，一个加速的伤口关闭与向下调节的炎症基因被观察到。

Cleft palate patients are often subject to maxillary growth impairment and narrow dental arch after surgical closure of the defect in infancy. This is considered to be a consequence of the scar which is formed during palatal wound healing. Smad3 is one of the members concerned to TGF-・signaling pathway、and its deficient mice showed the notably accelerated wound healing in injured palates. In this study、we investigated the effects of the inhibition of Smad3 gene expression in wound repair、and as a result、an accelerated wound closure with down regulation of inflammatory genes was observed.