Sensing mechanism of lipid asymmetry and cellular response

在质膜中，外叶和内叶的脂质组成不同。这种脂质不对称性的维持和适当改变对细胞活力至关重要。在这项工作中，我们确定了一个传感器蛋白，Rim 21，它检测脂质不对称的变化，体现了一个新的概念，细胞监测脂质不对称的状态。我们还发现了一个新的因子，Opt2，它作为Rim 21的下游事件被诱导，并被认为在修复紊乱的脂质不对称性中起作用。

In the plasma membrane, lipid composition differs between the outerand inner leaflet. Maintenance and proper alteration in such lipid asymmetry is essential for cellviability. In this work, we identified a sensor protein, Rim21, which detects alteration in lipidasymmetry, embodying a novel concept that cells monitor the status of lipid asymmetry. We alsofound a novel factor, Opt2, which is induced as a downstream event of Rim21, and is considered toact in mending of disturbed lipid asymmetry.