Research for a mechanism for generation of GnRH pulse regulated by neural activity of kisspeptin neurons in the arcuate nucleus

弓状核(ARC)内的Kispeptin神经元可能参与调节GnRH/LH的节律性分泌。大多数神经元的神经活动可能会同时爆发，但这种现象的机制仍不清楚。在这项研究中，我们讨论了如何控制大多数ARC kispeptin神经元同时爆发的机制。ARC kispeptin神经元在对侧和同侧通过纤维相互形成神经网络。神经活动记录显示，两侧ARC-Kispeptin神经元的神经活动是同步的。这些结果表明，大多数ARC Kispeptin神经元的同步神经活动可能是由神经网络利用其纤维来控制的。

Kisspeptin neurons in the arcuate nucleus (ARC) might regulate pulsatile secretion of GnRH/LH. Neural activity of the majority of these neurons might burst simultaneously, however a mechanism for this phenomenon still remains unclear. In this study, we addressed how mechanism controls the simultaneous burst of majority of the ARC kisspeptin neurons. The ARC kisspeptin neurons have neural network each other by their fibers in the contralateral as well as ipsilateral side. And recording of neural activity revealed that neural activity of ARC kisspeptin neurons from both side were synchronized. These results suggest that synchronized neural activity of majority of ARC kisspeptin neurons might be controlled by neural network using their fibers.