Breaking immunological tolerance to canine malignant melanoma using anti-Gpnmb antibody and various antigen peptides associated with tumor.

本研究利用抗Gpnmb抗体和多种肿瘤相关抗原肽，探索了犬恶性黑色素瘤免疫治疗的新途径。研究表明，与常规方法相比，某些肽显著激活T淋巴细胞。然而，使用抗Gpnmb Ab的实验在T细胞活化方面未显示出显著结果。在未来的研究中，我们将彻底检查实验条件，并打算找到更有效的免疫疗法。

We investigated new approachof immunological therapy for canine malignant melanoma, using anti-Gpnmb Ab and other various antigen peptides associated with tumor. The research showed that some peptides significantly activated T-lymphocytes compared to conventional method. However, the experiments with anti-Gpnmb Ab did not show notable results in T-cell activation. In the future research, we will thoroughly examine experimental conditions and intend to find more effective immunotherapy.