The regulation of local corticosteroid synthesis and its pathophysiological effect in the heart.

醛固酮在心力衰竭的发病机制中起着关键作用。在此，我们研究了心脏局部醛固酮合成的调节及其病理生理效应。我们证明了高糖环境促进了心肌细胞中醛固酮合成酶的表达。此外，短期的醛固酮刺激被发现通过以一种不依赖于盐皮质激素受体的方式急性激活胰岛素信号来保护心脏。这些结果为了解醛固酮作为病理条件下的代偿机制提供了新的视角，例如心力衰竭，在这种情况下，葡萄糖成为代谢和ATP生成的重要优先底物。

Aldosterone plays a pivotal role in the pathogenesis of heart failure. We herein investigated the regulation of the local aldosterone synthesis and its pathophysiological effects in the heart. We demonstrated that high glucose conditions promote the expression of aldosterone synthase in cardiomyocytes. Moreover, a short-term aldosterone stimulation is found to be cardioprotective through the acute activation of insulin signaling in a mineralocorticoid receptor-independent manner. These results provide new insight into the previously unknown role of aldosterone, as a compensatory mechanism under the pathological conditions, such as heart failure, where glucose becomes an important preferential substrate for metabolism and ATP generation.