Identification of new biomarkers for the prediction of disease onset and for therapy evaluation in preterm infants with bronchopulmonary dysplasia

在这里，我们研究了碳氧血红蛋白（CO-Hb）和高铁血红蛋白（Met-Hb），CO生产和NO生产的标志物，分别水平，并讨论这些标志物的有用性预测支气管肺发育不良（BPD）早产儿。出生后5-7天中/重度BPD组的CO-Hb水平显著高于无/轻度BPD组。尿氧化应激标志物的水平，即，晚期氧化蛋白产物（AOPP）和8-羟基脱氧鸟苷（8-OHdG），在出生后5-7天，中度/重度BPD的婴儿也倾向于高于无/轻度BPD的婴儿。因此，我们的数据表明，新生儿早期的高水平CO-Hb可能反映了氧化应激对血红素加氧酶-1（HO-1）的诱导，并且CO-Hb水平对于早产儿中度/重度BPD的早期预测是有用的。

Here, we examined levels of carboxyhemoglobin (CO-Hb) and methemoglobin (Met-Hb), markers of CO production and NO production, respectively, and discuss the usefulness of these markers to predict bronchopulmonary dysplasia (BPD) in preterm infants. CO-Hb levels in infants with moderate/severe BPD on postnatal days 5-7 were significantly higher than those in infants with no/mild BPD. Levels of urinary oxidative stress markers, i.e., advanced oxidative protein product (AOPP) and 8-hydroxydeoxyguanosine (8-OHdG), in infants with moderate/severe BPD also tended to be higher than those in infants with no/mild BPD on postnatal days 5-7. Thus, our data suggest that high levels of CO-Hb during the early neonatal period may reflect induction of hemeoxygenase-1 (HO-1) by oxidative stress and that CO-Hb levels are useful for early prediction of moderate/severe BPD in preterm infants.