Study on mood disorder pathogenesis using a novel animal model of bipolar disorders expressing protein of human herpesvirus.

人类疱疹病毒（HHV-）6 (SITH) -1的中间阶段转录物编码的小蛋白，是HHV-6的潜伏转录物，通过在小鼠星形胶质细胞中表达引起抑郁样行为。炎症细胞因子mRNA水平在小鼠大脑中没有变化。另一方面，炎症细胞因子mRNA血液水平和抑郁症状严重程度与人类患者的情绪障碍相关。外周血和中枢神经系统（CNS）的基因表达不一定一致。全身性炎症影响中枢神经系统，诱导SITH-1可引起抑郁症状。

Small protein encoded by the Intermediate stage Transcript of Human herpesvirus (HHV-)6 (SITH) -1, a latent transcript of HHV-6, causes depressive-like behavior by being expressed in mouse astrocytes. Inflammatory cytokine mRNA levels did not change in the brains of mice. On the other hand, inflammatory cytokine mRNA blood levels and depressive symptom severity were correlated with mood disorders in human patients. Gene expression in peripheral blood and the central nervous system (CNS) do not necessarily coincide. Systemic inflammation affects the CNS and induction of SITH-1 may cause depressive symptoms.