Detection system for the influenza virus by novel functional polymer and artificial enzyme

流感病毒上的血凝素蛋白可以识别细胞膜上的唾液酸，病毒感染人体细胞。在本研究中，我们利用这一机制制备了能够检测流感病毒的功能膜。采用辐射引发接枝聚合法制备了该功能膜。为了固定化作为流感病毒血凝素蛋白识别位点的唾液酸，将偶联的亚氨基二乙酸和1-乙基-3-碳二亚胺引入到中空纤维膜上。铜离子作为信号物质吸附在唾液酸固定的中空纤维膜上，表明该传感器用于流感病毒检测的可能性。

The hemagglutinin protein on influenza virus can recognize the sialic acid on the cell membrane, and the virus infects the human cell. In this study, we utilize this mechanism to prepare the functional membrane, which can detects the influenza virus. This functional membrane was prepared by radiation-induced graft polymerization. To immobilize the sialic acid as the recognition site of the hemagglutinin protein on the influenza virus, the coupled iminodiacetic acid and 1-ethyl-3-carbodiimide hydrochloride was introduced onto the porous hollow fiber membrane. Copper ion as a signal substance was adsorbed on the sialic acid immobilizesd porous hollow fiber membrane, and it indicated the possibility of the sensor for influenza virus.