Search for useful biomarkers for evaluation of antipruritic agents

我们利用慢性瘙痒的小鼠模型，寻找有用的生物标志物来评估血清和血浆中的止痒药物。发现慢性瘙痒小鼠血浆中促肾上腺皮质激素(ACTH)减少，这种减少可被抑制瘙痒行为的药物逆转。因此，ACTH可能是瘙痒和瘙痒相关应激的有用生物标志物。蛋白质组学分析揭示了颗粒酶A和一些血清蛋白的变化，仍被分析为可能的瘙痒生物标志物。

We searched useful biomarkers for evaluation of antipruritic agents in serum and plasma, using mouse models for chronic pruritus. Adrenocorticotropic hormone (ACTH) was found to be reduced in the plasma of mice with chronic pruritus, and this decrease was reversed by agents that inhibited itching behaviors. Thus, ACTH may be useful biomarkers for itching and itch-associated stress. Granzyme A and some serum protein, changes of which were revealed by proteomic analysis, are still analyzed as possible pruritus biomarkers.