Development of a monitoring system of in vivo cell dynamics for therapeutic evaluation of psychiatric disorders

据报道，神经干细胞不仅在正常的神经生长过程中，而且在神经精神疾病中发生的神经元变性过程中发生各种变化。尽管有这些发现，但还没有关于神经干细胞的生理和病理生理意义的研究。因此，我们试图开发一种体内监测系统，利用该系统可以可视化干细胞的动态。使用正电子发射断层扫描与一个新的基因报告系统和氨基酸转运蛋白，我们能够使一个新的在体内系统测量活的神经干细胞在体内特异性。

It has been reported that neural stem cells are variously changed in the process of not only normal neural growth but also neuronal degeneration occurring in neuropsychiatric disorders. Despite these findings, there was no study about the contribution of neural stem cells to the physiological and pathophysiological significance. Hence we tried to develop an in vivo monitoring system with which the dynamics of the stem cells can be visualized. Using positron emission tomography with a new gene-reporter system and amino acid transporter, we were able to make a new in vivo system for measuring live neural stem cells in vivo specifically.