Development of the fluorescence augmented reality navigation surgery to visualize the carcinoma tissue and sentinel lymph node

在肿瘤相关手术中，三维确定原发肿瘤的侵袭程度和受累淋巴结的部位是非常重要的，而前哨淋巴结的容易识别将提高治疗效果。如果能将肿瘤存在位置的信息放在患者的图像之上，作为外科医生的新眼睛在实时三维显示器上显示，很可能会显著提高图像引导手术的可操作性。在本研究中，我们通过引入最新的增强现实技术、荧光成像方法和图像传感技术，开发了在真实空间中三维可视化宏观不清晰的侵袭范围和转移灶的基础技术。利用机器视觉系统和高精度CCD相机在真实空间中进行位置测量，建立了精确匹配空间位置关系的空间坐标系统。

In cancer-related surgeries, while it is extremely important to three-dimensionally ascertain the invasion extent of primary tumor and the parts of involved lymph nodes, the easy identification of sentinel lymph nodes would improve the treatment results. If the information on the location where a tumor exists can be laid on top of a patient's image to be displayed on a real time three-dimensional display as a surgeon's new eyes, it is likely that the operability of image-guided surgery is improved markedly. In the study, we developed the fundamental technology to visualize the macroscopically unclear invasion extent and metastatic focus three-dimensionally in real space by introducing the newest augmented reality technology, fluorescence imaging method, and picture sensing technology. The system which specifies the space coordinates for accurate matching of a spatial positional relationship using the machine vision system with a high precision CCD camera for position measurement in real space was established.