The novel periodontal regeneration therapy optimized for tissue engineered cell culture treatment by using the full metal barrier

为了改善现有模型阻隔膜的物理性能，利用微细加工技术制作了20μm孔径的高密度纯钛膜，实现了新型阻隔膜。它在韧性和耐久性上具有显著的优势，能够稳定组织再生空间，有助于建立复制目标组织，还可以防止口腔微生物的污染。与现有的屏障膜相比，新的钛膜相对节省了厚度，消除了组织再生体积对空间的影响。在人牙周膜细胞的培养实验中，新型钛膜表现出良好的支持细胞附着、迁移和增殖的性能，有望成功地实现牙周组织的再生。它的有效性已经在用比格犬进行的动物试验中得到了证实。

In order to improve the physical property of the current model of the barrier membrane, the new style of the barrier membrane has implemented by using microfabrication technology to create high-density form of 20 μm pored pure titanium membrane. It has a significant advantage on the toughness and durability to stabilized a tissue regeneration space to contribute establish to reproduce the target tissue, and also on the prevention of a contamination by oral microorganisms. The new titanium membrane is relatively saved a thickness that eliminated a tissue regeneration volume to be compromised the space in comparison with the one of the current models of barrier membrane. membrane.On the culture test by using human periodontal ligament-derived cells, the new titanium membrane showed excellent properties supporting cell attachment, migration and proliferation to be promising the periodontal tissue regeneration successfully. Its usefulness has been confirmed in the animal test using beagle dogs.