Flow Dynamics of Liposome-encapsulated Hemoglobin in MicrovascularLevel including Oxygen Release Process

典型的脂质体包裹血红蛋白（LEH）颗粒直径约为200-250纳米。因此，LEH在微循环水平的影响将是显著的，在微循环水平，血管直径小于红细胞（RBC）直径。因此，研究红细胞和LEH在微血管中的流动分布将有助于更好地了解LEH对组织氧输送的影响。在这项研究中，我们研究了氧气和LEH在微血管中的扩散。仿真结果表明，仿真结果与实验结果基本吻合。LEH扩散系数的增大导致浓度向径向扩散，导致微血管内氧浓度随时间增加，氧饱和度降低。

Typical liposome-encapsulated hemoglobin (LEH) particles measure approximately 200-250 nm in diameter. Thus the effect of LEH will be significant at a microcirculation level, where vessel diameters are smaller than the red blood cell (RBC) diameter. Therefore, studies on RBC and LEH flow distributions at a microvessel will provide a better understanding of the effect of LEH on tissue oxygen delivery. In this study, we investigated the diffusion of oxygen and LEH in the microvessel. The simulation results showed the qualitative agreement between the simulation and the experimental data. The increase on diffusion coefficient of LEH led to the concentration diffusion to the radial direction, as a result, the oxygen concentration increased as times passed and the oxygen saturation decreased in the microvessel.