Numerical Study on Transport Process of Liposome-encapsulated Hemoglobin in Microvascular Flow with Considering Erythrocyte Aggregation

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Flow analysis at microvascular bifurcation after partial replacement of red blood cell (RBC) with liposome-encapsulated hemoglobin (LEH) was performed. When the half of RBCs was replaced by isovolumic LEH particles, the biasing of RBC flow was enhanced. However, LEH particles flowed favorably into the lower-flow branch because many LEH particles within the parent vessel were suspended in the plasma layer that is impenetrable to RBCs. The biasing of the RBC flux was enhanced when the RBC aggregation was taken into account in the model. It was clarified that the RBC aggregation-induced change of the plasma layer thickness has a marked influence on the fractional LEH flux at the microvascular bifurcation.