Numerical Study on Transport Process of Liposome-encapsulated Hemoglobin in Microvascular Flow with Considering Erythrocyte Aggregation

考虑红细胞聚集的脂质体包裹血红蛋白在微血管流中转运过程的数值研究

• 批准号: 21700467
• 负责人: HYAKUTAKE Toru
• 金额: $ 2.83万
• 依托单位: Yokohama National University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700467/
• 关键词: 微小循環; 格子ボルツマン法; 人工赤血球; 埋め込み境界法

Flow analysis at microvascular bifurcation after partial replacement of red blood cell (RBC) with liposome-encapsulated hemoglobin (LEH) was performed. When the half of RBCs was replaced by isovolumic LEH particles, the biasing of RBC flow was enhanced. However, LEH particles flowed favorably into the lower-flow branch because many LEH particles within the parent vessel were suspended in the plasma layer that is impenetrable to RBCs. The biasing of the RBC flux was enhanced when the RBC aggregation was taken into account in the model. It was clarified that the RBC aggregation-induced change of the plasma layer thickness has a marked influence on the fractional LEH flux at the microvascular bifurcation.

对脂质体包裹的血红蛋白(LEH)部分置换红细胞(RBC)后微血管分叉处的血流进行了分析。当红细胞的一半被等体积的LEH颗粒取代时，红细胞流动的偏置增强。然而，由于母体血管内的许多LEH颗粒悬浮在红细胞无法穿透的血浆层中，因此LEH颗粒有利于流入较低的流动分支。当模型中考虑了红细胞聚集时，增强了红细胞通量的偏置。结果表明，红细胞聚集引起的血浆层厚度变化对微血管分叉处的LEH流量分数有显著影响。

项目成果

A Numerical Study on Flows of Red Blood Cells with Liposomeencapsulated Hemoglobin at Microvascular Bifurcation by Lattice Boltzmann Method

格子玻尔兹曼法对微血管分叉处脂质体包裹血红蛋白红细胞流动的数值研究

• 发表时间: 2009
• 作者: Naruse;Y.;Takiyama;K.;Okada;M. & Murata;T;Toru Hyakutake
• 通讯作者: Toru Hyakutake

Numerical study on flows of red blood cells with liposome-encapsulated hemoglobin at microvascular bifurcation

• DOI: 10.1115/1.2838024
• 发表时间: 2008-02-01
• 期刊: JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
• 影响因子: 1.7
• 作者: Hyakutake, Toru;Tominaga, Shouko;Yanase, Shinichiro
• 通讯作者: Yanase, Shinichiro

Application of a numerical simulation to improve the separation efficiency of a sperm sorter

• DOI: 10.1007/s10544-008-9207-2
• 发表时间: 2009-02
• 期刊: Biomedical Microdevices
• 影响因子: 2.8
• 作者: T. Hyakutake;Y. Hashimoto;S. Yanase;K. Matsuura;K. Naruse

微小循環系でのナノ粒子の不思議な流れ

纳米粒子在微循环系统中的神秘流动

• 发表时间: 2009
• 作者: Shimayoshi;Takao;百武徹
• 通讯作者: 百武徹

微小分岐部内での病的な赤血球動態に対する人工赤血球の効果に関する数値解析

人工红细胞对微分叉内病理性红细胞动力学影响的数值分析

• 发表时间: 2010
• 作者: 百武徹;谷茂樹;赤木裕貴;松本健志;柳瀬眞一郎
• 通讯作者: 柳瀬眞一郎