A method for assessing the blood compatibility of ventricular assist systems using computational thermal fluid dynamics analysis

心室辅助装置（VAD）的血液相容性取决于血流动力学。以往大多数研究的重点是VAD内的血流。然而，VAD流入管会影响血流动力学，从而影响心室血栓的形成。为了明确连续流型VAD （CFVAD）支持下左心室（LV）的血流情况，采用数值和实验流体力学方法对其血流进行了分析。根据左室壁的平均壁剪应力评估表明，导管尖端形状和插入深度的某些组合改善了冲洗效果。计算部分支持CFVAD的左室血流量。确定了左室射血分数、VAD类型和泵性能对流型的影响。此外，还提出了一种评估血细胞脆弱性的简单方法。该方法对检测溶血试验用血细胞的质量有一定的参考价值。

Blood compatibility of a ventricular assist device (VAD) depends on the dynamics of blood flow. The focus in most previous studies was on blood flow in the VAD. However, the VAD inflow cannula influences the dynamics of blood flow and thus thrombus formation in the ventricle. In order to clarify the blood flow in the left ventricle (LV) supported with a continuous flow type VAD (CFVAD), the flow was analyzed by means of numerical and experimental fluid dynamics. Assessment based on average wall shear stress on the LV wall indicated that some of the combinations of the catheter tip shape and insertion depth improved the washout effect. The blood flow in the LV partially supported with a CFVAD was calculated. The change of flow pattern due to the LV ejection fraction, type of VAD and pump performance was confirmed. In addition, a simple method to assess the fragility of blood cells was proposed. The method is valuable to inspect the quality of the blood cells used for hemolysis tests.