Explorative Investigation of Endemic Jordanian Cyanobacteria with Respect to Medical and Ecological Implications

蓝藻毒素对野生动物和家畜的健康构成越来越大的风险，对人类也是如此。到目前为止，已经从这些来源分离出了大约900种天然产物，其中许多具有与其他来源的天然产物不同的结构。与这些尚待探索的蓝藻的估计数量相比，这似乎仍然很少。从医学或生态学的角度进一步调查蓝藻及其毒素，特别是在约旦等发展中国家。然而，仍然有许多化学问题和基础研究的问题需要回答：关于蓝藻本身或相关微生物负责这种高度多样性代谢物的问题有很多猜测，化学多样性肯定比目前已知的要高。该项目的目的是调查约旦特有的蓝藻菌群的化学和微生物学，相对于医学和免疫学的影响。为此目的，将对当地菌株进行广泛的生物和化学筛选。在第二步，选择的菌株将扩大规模，以获得足够的细胞材料进行化学研究。代谢物的结构评估将使用现代分析和光谱方法进行。作为该计划的一部分，某些化合物可能需要化学修饰，甚至需要进行结构/活性分析的全合成研究。

Cyanobacterial toxins are representing an increasing risk for the health of wild and demestic animals but also for humans. About 900 natural products have been isolated so far from these sources, many of them with structures which do not resemble natural products from other sources. Compared with the estimated number of these bluegreen algae still to be explored, this seems still to be little. Further investigation of cyanobactereia and their toxins of high interest from a medical or ecological point of view, especially in developing countries like Jordan. However, alsomany chemical questions and problems of basic research are still to be answered: There is much speculation about the question of the cyanobacteria itself or associated microorganisms are responsible for this high diversity of metabolites, and the chemical diversity is certainly higher than presently known. Aim of the project is to investigate the endemic Jordanian cyanobacterial flora chemically an dmicrobiologically, with respect to medical and exological implications. For this purpose, a broad biological and chemical screening of local strains will be performed. In a second step, selectid strains will be upscaled to gain sufficient cell material for chemical investigation. The structure evaluation of metabolites will be performed using modern analytical and spectrometric methods. As part of the program, certain compounds may require chemical modification or even studies for a total synthesis for structure/activity analysis.