Involvement of soluble CD155 in cancer immune escape

小鼠CD155只有膜结合形式，而人CD155也有可溶性剪接异构体(SCD155)，缺少跨膜区。在这里，我们显示癌症患者血清中的sCD155浓度显著高于健康献血者。为了分析sCD155在肿瘤免疫中的功能作用，我们建立了表达sCD155的META转基因细胞。与接种模拟转基因小鼠相比，接种表达sCD155的Metha转基因小鼠的肿瘤发展速度更快，生存时间更短。这些结果表明，sCD155参与了人类对癌症的免疫逃逸。

Mouse CD155 has only a membrane-bound form, but human CD155 has also soluble splice isoforms (sCD155) lacking the transmembrane region. Here, we show that cancer patients showed significantly higher concentration of sCD155 in the sera than healthy donors. To analyze the functional role of sCD155 in tumor immunity, we established MethA transfectant expressing sCD155. Mice inoculated with MethA transfectant expressing sCD155 showed increased tumor development and shorter survival, compared with mice inoculated with mock transfectant. These results suggest that sCD155 is involved in cancer immune escape in human.