Toxicological Research in Africa; The risk assessment that paid attention to drug metabolism species specificity

我们注意到了药物代谢的II相结合反应，并对野生动物进行了前药物代谢的物种特异性测定。通过对11种哺乳动物尿液的筛选，在被认为硫酸盐结合活性较低的猪中检测到了芘的硫酸盐结合。此外，通过动力学分析发现，猪的酶效率高于大鼠。然而，在非洲进行的调查中，我们获得了两栖动物、哺乳动物、鸟类尿液和一个器官。由于主要对重金属和农药进行了化学分析，在一些地区检测到了浓度极高的化学物质，特别是在鸟类中观察到了化学物质积累水平高于其他生物物种的趋势。

We paid attention to a drug metabolism phase II conjugation reaction and determined species specificity of pro-drug metabolism for the wild animal. Sulfate conjugation of pyrene was detected in the pigs which had been thought to have low sulfate conjugation activity by the screening using 11 kinds of mammalian urine. Also, as a result of kinetics analysis, it was found that the enzyme efficiency of the pig was higher than a rat. Whereas, in the investigation carried out in Africa, we obtained amphibians, mammals, avian urine and an organ. As a result of having performed chemical analysis mainly on heavy metal and pesticides, an extremely highly-concentrated chemical was detected in some areas, and the tendency that accumulated a chemical at the level that was higherthan other organism species in birds particularly was observed.