NANOCHEMICAL PATTERNING COMBINING SELECTIVE MOLECULAR ASSEMBLY SYSTEMS AND COLLOIDAL LITHOGRAPHY (NANO-SMAP)

拟议的项目“NANO-SMAP”解决了多功能分子在氧化物表面的位点特异性自发分子组织，以产生生物功能和特异性的几何定义的表面图案。kleiner als 100 nm，最终kleiner 10 nm特征尺寸的（识别）化学该项目结合了项目合作伙伴在四个领域的具体专业知识：a）用于通过胶体平版印刷生产预图案化无机基底表面的胶体纳米尺寸颗粒的受控组装; B）多官能烷烃磷酸酯和聚磷酸酯的合成和表征（乙二醇）-接枝共聚物，其分别选择性地组装在TiO 2和SiO 2表面上; c）基于选择性分子组装系统烷烃磷酸盐、PEG共聚物和支撑的磷脂脂质双层，在非交互背景中产生具有交互区域的表面图案（SPB，来自囊泡）;和d）在与生物材料和生物传感器应用相关的模型生物测定中测试所得表面结构。该项目预计将提供一种新的平台技术，用于基于具有自组织特性的分子和胶体系统工具箱的生物相关纳米级界面架构的成本效益生产。

The proposed project "NANO-SMAP" addresses the site-specific spontaneous molecular organization of multifunctional molecules at oxide surfaces to produce geometrically defined surface patterns of biologically functional and specific (recognition) chemistry with feature dimensions of kleiner als 100 nm, ultimately kleiner 10 nm The project combines specific expertise of the project partners in four areas: a) the controlled assembly of colloidal nanosized particles for the production of pre-patterned inorganic substrate surfaces by colloidal lithography; b) the synthesis and characterization of multifunctional alkane phosphates and poly(ethylene glycol)-grafted polyelectrolyte copolymers that selectively assemble on TiO2 and SiO2 surfaces, respectively; c) the production of surface patterns with interactive areas in a non-interactive background based on the selective molecular assembly systems alkane phosphates, PEG-copolymers and supported phospholipid lipid bilayers (SPB, from vesicles); and d) the testing of the resulting surface architectures in model bioassays related to biomaterial and biosensor applications. The project is expected to deliver a novel platform technology for the cost-effective production of biologically relevant nanoscale interface architectures based on a toolbox of molecular and colloidal systems with self-organizing properties.