Post-genomic investigation of the relict plastid and mitochondrion of malaria parasites

疟疾是一个主要的全球健康问题。疟疾寄生虫有两个亚结构，一个是废弃的叶绿体，一个是线粒体，它们是新药物和现有药物的极好靶点。然而，我们不知道这两个隔间的关键功能。疟疾寄生虫的整个基因蓝图（基因组）现在是可用的，我建议准确确定基因组的哪些部分是为残余的叶绿体和线粒体服务的。这将勾勒出它们的内部工作原理。有了这些信息，我们可以采取理性的方法来寻找阿喀琉斯？可以开发针对寄生虫的药物的疟疾的脚跟。

Malaria is a major global health problem. The malaria parasite has two substructures, a relict chloroplast and a mitochondrion, that are excellent targets for new and existing drugs. However, we do not know the key functions of these two compartments. The entire genetic blueprint (genome) is now available for the malaria parasite and I propose to determine exactly which parts of the genome service the relict chloroplast and mitochondria. This will sketch out a picture of their inner workings. Armed with this information we can take a rational approach to seeking an Achilles? Heel of malaria against which parasite-specific drugs can be developed.