BIo-Organics NanostructurIng for molecular electroniCS (BIONICS)

该项目将结合分子生物学和化学，构建基于DNA网络的新型混合生物有机大分子和纳米结构。两条互补DNA链之间的结合是一种灵活且可编程的特异性分子识别过程，可以在合成规模上使用。大分子，如共轭低聚物或树枝状聚合物，可以合成为在多个位置具有反应性官能化和从nm到mm尺度的限定空间形状。我们提出了一个合理的协议，用于制备混合生物有机积木作为星形的“基石”在一个基于DNA的架构。对结构单元的官能团的控制将使组装的介观结构能够实现程序化的功能和结构变化，并将获得平面或三维、线性、分支或网状结构。对含发色团结构的空间和时间分辨荧光测量以及扫描探针显微镜将使人们深入了解结构单元和介观结构的物理化学性质，这对于未来开发新的分子（光）电子器件是必要的。 Niederländischer Kostenplan（2）：a）人事费（3年）138.000，00 EUR B）材料费（3年）42.000，00 EUR总计180.000，00 EUR Italienischer Kostenplan（3）：a）人事费（3年）120.000，00 EUR B）材料费（3年）57.998，00 EUR总计177.998，00 EUR Italienischer Kostenplan（4）：a）人员费用（3年）120.000，00欧元B）材料费用（3年）258.000，00欧元总计378.000，00欧元设备：STM和SFM在空气、液体和气体中运行200.000，00 EUR升级分子力学模拟工作站25.000，00 EUR Belgischer Kostenplan（5）：a）人事费（3年）180.000，00 EUR B）材料费（3年）33.000，00 EUR总计213.000，00 EUR Englischer Kostenplan（6）：a）人事费（3年）138.990，00 EUR B）材料费（3年）66.000，00 EUR总计204.990，00 EUR

This project will bring together molecular biology and chemistry to construct new hybrid bio-organic macromolecules and nanostructures based on DNA networks. Binding between two complementary DNA-strands is a flexible and programmable specific molecular recognition process that can be employed on a synthetic scale. Macromolecules, such as conjugated oligomers or dendrimers, can be synthesised to have reactive functionalisations at multiple locations and a defined spatial shape spanning from the nm to the mm scale. We propose a rational protocol for the preparation of hybrid bio-organic building blocks serving as star-shaped "corner stones" in a DNA-based architecture. Control over the functional groups of the building blocks will enable programmed functional and structural changes to the assembled mesoscopic structures and will give access to planar or three-dimensional, linear, branched or reticulated structures. Space- and time-resolved fluorescence measurements on chromophore- containing architectures as well as scanning probe microscopy will grant insights into the physico-chemical properties of the building blocks and of the mesoscopic struc - tures, necessary for the future development of new molecular (opto)electronic devices. Niederländischer Kostenplan (2): a) personnel costs (3 years) 138.000,00 EUR b) material costs (3 years) 42.000,00 EUR Total 180.000,00 EUR Italienischer Kostenplan (3): a) personnel costs (3 years) 120.000,00 EUR b) material costs (3 years) 57.998,00 EUR Total 177.998,00 EUR Italienischer Kostenplan (4): a) personnel costs (3 years) 120.000,00 EUR b) material costs (3 years) 258.000,00 EUR Total 378.000,00 EUR Equipment: STM and SFM operating in air, liquid and under gases 200.000,00 EUR Upgrade workstations for Molecular Mechanics simulations 25.000,00 EUR Belgischer Kostenplan (5): a) personnel costs (3 years) 180.000,00 EUR b) material costs (3 years) 33.000,00 EUR Total 213.000,00 EUR Englischer Kostenplan (6): a) personnel costs (3 years) 138.990,00 EUR b) material costs (3 years) 66.000,00 EUR Total 204.990,00 EUR Vorgutachten und Stellungnahme des Review-Panel: siehe folgende Seiten