Theoretical Studies on the KcsA Potassium Channel and the L-type Calcium Channel

大脑中的所有电活动都由离子通道的打开和关闭来调节。因此，了解它们的机制是生物学中的一个基本问题。该项目旨在开发两种重要类型离子通道的理论模型。使用超级计算机，我们将首先推导出由蛋白质壁形成的微结构的形状。然后，利用计算机模拟技术，我们将构建一套生物离子通道的物理模型，该模型将正确地复制实验观测。这样的理论将通过物理学的基本原理将离子通道的结构和功能联系起来。

All electrical activities in the brain are regulated by opening and closing of ion channels. Thus, understanding their mechanisms is a fundamental problem in biology. The project is aimed at developing a theoretical model of two important types of ion channels. Using a supercomputer, we will first deduce the shape of the microstructure formed by a protein wall. Then, using a computer simulation technique, we will construct a set of physical models of biological ion channels, which will correctly replicate experimental observations. Such a theory will link the structure and function of an ion channel through the fundamental principles of physics.