Immunological analysis of alopecia areata

以白细胞介素-17 （IL-17）产生为特征的T辅助17细胞在包括斑秃（AA）在内的自身免疫性疾病的发病机制中起关键作用。我们对il -17产生细胞、干扰素- γ产生细胞、颗粒蛋白携带细胞和Foxp3+调节性T细胞进行免疫组化染色，并对几种临床形式AA的病变皮肤中il -17产生细胞进行了TissueFAXS分析。其中，有趣的是，急性脱发、弥漫性脱发和全秃中产生il -17的细胞比例明显低于多种AA型。我们的研究揭示了AA的一种可能的免疫机制。

T helper 17 cells, characterized by interleukin-17 (IL-17) production, play a critical role in the pathogenesis of autoimmune disease, including alopecia areata (AA). We employed immunohistochemical staining for IL-17-producing cells, as well as interferon-gamma-producing cells, granulysin-bearing cells and Foxp3+ regulatory T cells, and performed a quantitative analysis of IL-17-producing cells in the lesional skin of several clinical forms of AA by TissueFAXS analysis. Among them, interestingly, the ratio of IL-17-producing cells in acute, diffuse and total alopecia was significantly lower than those of multiple types of AA. Our study sheds light on one of the possible immunological mechanisms of AA.