Analysis of the mechanism for dendritic cell maturation by haptens
Analysis of the mechanism for dendritic cell maturation by haptens
批准号:
20790785
负责人:
MIZUASHI Masato
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
In this study, we examined whether sensitizers oxidize cell surface thiols of monocyte-derived dendritic cells (MoDCs). All the sensitizers that we examined decreased cell surface thiols on MoDCs. Our data suggest that the oxidation of cell surface thiols have some role in triggering DC maturation by sensitizers. In addition, we also suggest that both ER stress and CD40 ligand derived from platelets are related to DC maturation by sensitizers.
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会议论文
Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production
用柴油机尾气颗粒或甲醛处理的人类 T 细胞中的分子事件导致其干扰素 γ 和白细胞介素 10 的产生减少
DOI:
--
发表时间:
2009
期刊:
Int Arch Allergy Immunol 148
影响因子:
--
作者:
[Sasaki Y, Ohtani T, Ito Y, Mizuashi M, Nakagawa S, Furukawa T, Aiba S]
通讯作者:
Aiba S
DOI:
10.1038/jid.2009.229
发表时间:
2010-01-01
期刊:
JOURNAL OF INVESTIGATIVE DERMATOLOGY
影响因子:
6.5
作者:
[Kagatani, Saori, Sasaki, Yoshinori, Aiba, Setsuya]
通讯作者:
Aiba, Setsuya
TGF-〓l dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation
TGF-〓l 抑制树突状细胞对环境刺激的敏感性,导致需要危险信号来激活
DOI:
--
发表时间:
2009
期刊:
Immunology 126
影响因子:
--
作者:
[Ohtani T, Mizuashi M, Nakagawa S, Sasaki Y, Fujimura T, Okuyama R, Aiba S.]
通讯作者:
Aiba S.
Immunological analysis of alopecia areata
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批准号:24791132
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.58万
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财政年份:2012
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负责人:MIZUASHI Masato
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依托单位:
海外基金