Anti-IL-6 antibody attenuates TNF-alpha and cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
Anti-IL-6 antibody attenuates TNF-alpha and cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
抗 IL-6 抗体可减轻压疮小鼠模型中的 TNF-α 和皮肤缺血再灌注损伤
批准号：
24791142
负责人：
SAITO Yuki
金额：
$2.75万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2012
资助国家：
日本
项目状态：
已结题
起止时间：
2012-04-01 至 2014-03-31
中文摘要
翻译
在小鼠皮肤缺血再灌注损伤模型上，局部应用抗IL-6抗体可抑制肿瘤坏死因子-α和诱导型一氧化氮合酶的表达，并降低其细胞毒性。并对皮内注射抗IL-6抗体的安全性进行了检查，由此提出抗IL-6抗体治疗可预防压疮的发生。
英文摘要
In a mouse model of cutaneous ischemia-reperfusion injury, local administration of anti-IL-6 antibody inhibited expression of TNF-alpha and inducible nitric oxide synthase, and reduced cytotoxicity of them. And we checked the safeness about intradermal injection with anti-IL-6 antibody.From that reason, I suggest that anti-IL-6 antibody treatment might prevent the pressure ulcers.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Clinical significance of organ stiffness in patients with acute decompensated heart failure
-
批准号：20K17164
-
项目类别：Grant-in-Aid for Early-Career Scientists
-
资助金额：$0.75万
-
财政年份：2020
-
负责人：SAITO Yuki
-
依托单位：
Physiological role of the 5HT1AR in the regulation of sleep/wakefulness states
-
批准号：16K21057
-
项目类别：Grant-in-Aid for Young Scientists (B)
-
资助金额：$2.5万
-
财政年份：2016
-
负责人：SAITO Yuki
-
依托单位：
Anti-TNF-alpha antibody attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
-
批准号：22791062
-
项目类别：Grant-in-Aid for Young Scientists (B)
-
资助金额：$2.58万
-
财政年份：2010
-
负责人：SAITO Yuki
-
依托单位：
Protection of Surety
-
批准号：18730056
-
项目类别：Grant-in-Aid for Young Scientists (B)
-
资助金额：$1.99万
-
财政年份：2006
-
负责人：SAITO Yuki
-
依托单位：
海外基金
