Relationship between Peri-implant Bone Metabolism and immediate Loading using [18F]NaF-PET Image Analyses

CT和[18 F]NaF-PET可以精确估计牙种植体周围的骨代谢、骨密度和骨小梁结构。组织学检查显示种植体周围有明显的成骨反应，与骨代谢和骨密度有关，应用[18 F]NaF-PET能准确、三维地评价种植体周围的骨代谢。结果提示早期加载对种植体周围骨形成有影响。与我们以前用Tc 99 m-MDP骨显像的结果相比，本研究显示了不同的骨代谢方式。这些差异可能是由于两种示踪剂（即18F-和MDP）之间的摄取机制不同所致。

CT and [18F]NaF-PET allowed for a precise estimate of bone metabolism, bone density and trabecular bone structure around the dental implants. Histological deta clearly showed osteogenic reaction around the implants, which related bone metabolism and bone density.Using [18F]NaF-PET, bone metabolism around the implant could be estimated precisely and three-dimensionally. The result suggests the loading effects in early stage on peri-implant bone formation. Comparing with our previous data using Tc99m-MDP bone-scintigraphy, the results of this study showed different manners of bone-metabolism. Those differences might be due to a difference of uptake mechanisms between 2 tracers, namely 18F- and MDP.