Regulatory mechanisms for spatiotemporal dynamics of condensins I and II

大多数真核生物利用两种不同的凝聚素复合物（称为凝聚素I和II）来调节有丝分裂染色体的组装和分离。然而，有趣的是，凝聚素I和II在间期表现出不同的亚细胞定位。在这项研究中，我已经解决了这两个复合物的亚细胞定位是如何建立在哺乳动物受精卵和体细胞的问题。结果发现，由输出蛋白的凝聚素I的核输出是负责的本地化模式，这似乎是在哺乳动物的增殖细胞之间的保守。

Most eukaryotes utilize two different condensin complexes (known as condensins I and II) to regulate mitotic chromosome assembly and segregation. Interestingly, however, condensins I and II exhibit different subcellular localization during interphase. In this study, I have addressed the question of how the subcellular localization of the two complexes is established in mammalian fertilized eggs and somatic cells. It was found that nuclear export of condensin I by an exportin is responsible for the localization pattern, which appears to be conserved among proliferative cells in mammals.