Regulation of tryptophan metabolism by organic anion transporters

在这项研究中，我进行了药物转运实验，以检查色氨酸代谢物与有机阴离子转运体OAT1和OAT3的相互作用。结果表明，犬尿酸和黄嘌呤酸是这两种转运体的底物，并且表明OAT1和OAT3参与了代谢产物的处置。由于犬尿酸在大脑中的异常水平与几种精神疾病有关，因此与燕麦转运的关系是有趣的。大鼠静脉输注黄嘌呤酸观察尿钠现象。同时服用一种典型的OAT抑制剂probenecid后，这种效果消失。因此，我们认为黄嘌呤酸转运在黄嘌呤的输钠过程中起一定的作用。

In this study, I performed drug transport experiments to examine interaction of tryptophan metabolites with organic anion transporters OAT1 and OAT3. The results show that kynurenic acid and xanthurenic acid are the substrates of both transporters, and suggest that OAT1 and OAT3 contribute to the disposition of the metabolites. Because abnormal levels of kynurenic acid in the brain link to several psychiatric disorders, relationship with the transport by OATs is interesting.By intravenous infusion of xanthurenic acid to rats, natriuresis was observed. This effect disappeared by simultaneous administration of probenecid, a representative inhibitor of OAT. Accordingly, it is suggested that xanthurenic acid transport by OAT plays a role in its natriuresis.