Analysis of intracellular pathogenesis of Legionella in the host

嗜肺军团菌是一种能引起严重肺炎的病原微生物。在嗜肺乳杆菌对宿主细胞的感染中，嗜肺乳杆菌劫持细胞内转运途径和军团菌效应蛋白在这种劫持中起着至关重要的作用。在这项研究中，我揭示了军团菌效应蛋白之一DrrA操纵胞外复合体(宿主蛋白复合体)，该复合体与胞内转运有关，而DrrA操纵胞外复合体是嗜肺乳杆菌有效生长所必需的。

Legionella pneumophila (L. pneumophila) is a pathogenic microbe that cause sever pneumonia. In L. pneumophila infection to the host cell, L. pneumophila hijack intracellular trafficking pathway and Legionella effector proteins that are secreted from the L. pneumophila to the host cell play a crucial role in this hijacking. In this study, I revealed that one of the Legionella effector protein, DrrA manipulates exocyst complex (host protein complex) that is implicated in the intracellular trafficking and manipulation of exocyst complex by DrrA is required for the effective intracellular growth of L. pneumophila.