Development of Closed-loop Implantable Focal Brain Cooling System for non-human primates

局灶性脑降温对癫痫等多种神经系统疾病具有治疗潜力。在这项研究中，我开发了一种可实现闭环系统的植入式降温装置。降温装置由一个用于冷却大脑的PID控制的热电芯片和一个用于散热的蓄热器组成。该冷却系统在猫体内的半植入实验表明，该系统可以控制目标温度。然后将该装置改装并植入成年猴子体内。然而，冷却性能也受到了限制。基于频谱分析的棘波检测方法是应用最优降噪的有效发作检测方法。在未来，我正在考虑使用复杂解调方法和经验模式减压来实现分析。结果可能支持基于植入式局灶性脑降温装置的热神经调制的技术可行性。

Focal brain cooling has the therapeutic potential to various neurological diseases such as epilepsy. In this study, I developed a implantable cooling device that can be achieved with closed-loop system.The cooling device composed of a PID-controlled, thermoelectric chip for cooling the brain and a reservoir for dissipating heat from the device. Semi-implantation of the cooling system in cats indicated the system could be controlled target temperature. Then the device was modified and implanted in adult monkey. However, a limitation of cooling performance was seen. Spike detection method based on frequency analysis was the effective seizure detection by applying the optimal noise reduction. In the future, I'm considering the implementation of the analysis using the complex demodulation method and empirical mode decompression.The results potentially supported the technical feasibility of thermal neuromodulation based on the implantable focal brain cooling device.