Understanding the role of miRNAs in the biology of ageing muscle

骨骼肌是人体最大的器官，在维持独立生活和社会交往中起着至关重要的作用。随着年龄的增长，骨骼肌失去了建立新的肌肉蛋白质的能力。然而，骨骼肌衰老的生物学原理还没有得到很好的理解。MicroRNA（MiRNA）是骨骼肌生物学的重要调节因子。它们是否在衰老过程中发挥作用，以及它们如何随着年龄的增长调节肌肉蛋白质的合成，尚未得到研究。该项目旨在确定参与肌肉蛋白质合成的miRNA种类，并将更好地了解衰老骨骼肌的生物学。

Skeletal muscle is the largest organ in the body and plays a vital role in maintaining independent living and social interaction. As it ages, skeletal muscle loses its ability to build up new muscle proteins. However, the principles underlying the biology of skeletal muscle ageing are not well understood. MicroRNAs (MiRNAs) are essential regulators of skeletal muscle biology. Whether they play a role in the ageing process and how they regulate muscle protein synthesis as we age has not been investigated. This project aims to identify the MiRNA species involved in muscle protein synthesis and will provide a better understanding of the biology of ageing skeletal muscle.