Viral capsids as high-efficiency nanoreactors

该项目旨在开发最先进的单分子成像技术，以真实的时间可视化真实逆转录病毒衣壳内的DNA合成。该项目预计将通过利用尖端的荧光标记试剂和显微镜技术在病毒学、合成生物学和纳米技术领域产生新的知识。预期成果包括对逆转录病毒逆转录的全面描述，开发用于病毒研究的创新生物物理技术，以及了解天然纳米反应器中发挥作用的工程原理。该项目预计将为生物纳米技术提供先进的能力，使治疗，生物技术和合成生物学应用受益。

This project aims to develop state-of-the-art single-molecule imaging to visualise DNA synthesis inside authentic retroviral capsids in real time. The project expects to generate new knowledge in the fields of virology, synthetic biology, and nanotechnology by utilising cutting-edge fluorescent labelling reagents and microscopy technology. Expected outcomes include a comprehensive description of retrovirus reverse transcription, development of innovative biophysical techniques for the study of viruses, and an understanding of the engineering principles at play in natural nano-reactors. This project anticipates contributing advanced capabilities in bionanotechnology, benefiting therapeutic, biotechnology and synthetic biology applications.