分子認識界面に立脚した選択部－センサ一体型システムによる肺がんマーカー分子の識別

多孔结构被证明是一种很有前途的捕获生物分子的结构。然而，电学纳米传感器沟道上多孔结构的集成困难限制了其应用，本文提出了在晶体管生物传感器的氧化锌沟道上形成Kirkendall效应诱导的多孔结构的独创性策略。这种多孔结构是通过对覆盖有Al_2O_3的氧化锌纳米束进行原位热处理而形成的。多孔结构的形成归因于Al和Zn在Al_2O_3/ZnO界面不同扩散速率的Kirkendall效应。最后，通过集成的电学生物传感器观察了该传感器对CRP分析物的传感响应。我们相信，这一原创性的策略将为设计新型多孔性生物传感器奠定基础。

Porous structure is proved as a promising structure for capturing the biomolecules. However, the difficulty for integration of the porous structure on the channel of electrical nanosensors have limited the application.Here I proposed an original strategy of creating a kirkendall effect induced porous structure on ZnO channel of transistor-based biosensor. The porous structure was in-situ fabricated by annealing of an Al2O3 covered ZnO nanobeam. The formation of the porous structure was assigned to the kirkendall effect of different diffusion rates of Al and Zn at the interface of Al2O3/ZnO. At last, the sensing response to the CRP analytes was observed by the integrated electrical biosensor. We believe that this original strategy will be a foundation for designing a new type of porous-based biosensors.