SFB 273: Hyperthermia: Methodics and Clinics

合作研究中心273基于这样一种假设，即将肿瘤加热至40-43°C的温度范围会提高各种肿瘤治疗(放射治疗、化疗、免疫治疗、基因治疗等)的有效性。由于生物和生理机制的不同。因此，方法论的发展是至关重要的，因为加热特定的身体区域并在可容忍的功率下达到高温是首要目标。几个有条不紊的项目旨在设计和制造射频范围内合适的相控阵应用器。对于受控应用，必须特别改进变换网络。在规划系统中对转向参数进行了优化。在治疗过程中，需要使用磁共振断层扫描对温度图、灌注和辐射电场(电光传感器或网络中的特殊测量)进行监测。目前可用的商业治疗系统的临床评估已经在第三阶段研究中进行，与技术开发平行。目前存在局部进展性直肠癌、宫颈癌和前列腺癌的治疗策略，并进行了临床应用。要评估的基本参数是序贯化疗-放疗-热疗的相互作用和必要或理想的温度范围。肿瘤材料的放射学和分子生物学的治疗前、术中和介入后的研究为区域深度热疗提供了更多的信息。

The collaborative research centre 273 is based on the hypothesis that heating of tumours up to a temperature range of 40-43°C leads to an enhanced effectiveness of various oncological therapies (radiotherapy, chemotherapy, immune therapy, gene therapy etc.) due to different biological and physiological mechanisms. The methodical development, therefore, is of utmost importance where heating up a defined body area and attaining elevated temperatures at tolerable powers is the primary aim. Several methodical projects aim at designing and building a suitable phased array applicator in the radio frequency range. For a controlled application, the transforming networks must be particularly improved. The steering parameters are optimized in a planning system. During treatment, monitoring of temperatures maps, registration of perfusion and the radiated electrical fields (electro optical sensors or special measurements in the network) with magnetic resonance tomography is necessary. A clinical evaluation with presently available commercial therapy systems is already being carried out in phase III studies, parallell to the technological development. Treatment strategies for locally progressive rectum, cervical and prostate carcinomas exist presently, with their clinical application. Essential parameters to be evaluated is the interaction of sequential chemotherapy-radiotherapy-hyperthermia therapies and the necessary or desirable temperature ranges. Pretherapeutical, intra-operative and post-interventional investigations in radiology and molecular biology of tumor material give rise to further information in regional deep hyperthermia.