Infection Biology and Epidemiology of Staphylococci and Staphylococcal Diseases in South and Central Afrika

金黄色葡萄球菌仍然是引起侵袭性疾病的主要病原体，具有很高的发病率和死亡率。该病原体已对几乎所有可用的抗菌素产生耐药性，近年来，世界范围内医院和社区出现的多重耐药金黄色葡萄球菌克隆引起了对地方和全球卫生举措的重大关注。然而，与“经典”热带病相比，大多数非洲国家对金黄色葡萄球菌感染的菌株系统发育和流行、疾病类型以及相关发病率和死亡率几乎一无所知。因此，该提案由四个撒哈拉以南非洲和五个德国小组提交，重点关注金黄色葡萄球菌社区获得性疾病的登记，用先进的分型和毒力因子表达方法分离和鉴定临床分离株，以及符合glp的长期分离处理和科学数据库交换。新出现的信息将允许将金黄色葡萄球菌生物学与疾病过程联系起来，从而为未来合理的多方面干预提供基础，包括根据撒哈拉以南非洲的资源和需求量身定制的诊断、治疗和预防措施。此外，应用学术交流和研讨会计划以及基于共享标准和技术的病例确定和分离株鉴定将促进非洲国家和德国与该病原体的斗争。

Staphylococcus aureus continues to be a major pathogen causing invasive disease with high associated morbidity and mortality. The pathogen has acquired resistance against virtually all antimicrobials available, and in the recent years, the worldwide emergence of multiresistant S. aureus clones in hospitals and communities has spurred significant concern for local and global health initiatives. In contrast to the ‘classical’ tropical diseases, however, almost nothing is known on the strain phylogeny and prevalence, disease type, and associated morbidity and mortality of infections due to S. aureus in most African countries. This proposal submitted by four sub-Saharan African and five German groups thus focusses on a registry of S. aureus community-acquired disease, on the isolation and characterization of clinical isolates with advanced methods for typing and virulence factor expression, and on GLP-conform long-term isolate handling and scientific database exchange. Emerging information will allow to associate S. aureus biology with course of disease, and thus provide a basis for future rational multifaceted interventions including diagnostics, therapy, and preventive measures tailored to the resources and requirements of sub- Saharan Africa. Moreover, the applied academic exchange and workshop program as well as case ascertainment and isolate characterization based on shared criteria and techniques will foster the combat against this pathogen in African countries as well as in Germany.