Quantitative MRI Measurement of Cerebral Perfusion by Dynamic Susceptibility Contrast

脑灌注评估是急性卒中、动脉狭窄引起的慢性脑缺血的公认诊断工具。使用磁共振成像（MRI）的灌注测量显示出与其他方法相比具有上级潜力，其诊断价值涉及多种成像模式和缺失的辐照暴露。灌注的MRI测量是基于示踪剂通过脑组织及其供血动脉的比较。这种方法是在基本过程的物理学尚未完全理解的时候开发的。这表现在可靠性差的定量数据中，这阻碍了诊断预后、治疗控制、受试者间和受试者内的比较。最近，我们提出了一个解决方案，通过组织采用最新进展的基本物理的理解示踪剂通道相关的问题。尽管研究界努力寻找解决方案，但关于示踪剂通过供血动脉的测量的剩余问题仍然存在。有了这个建议，我们的目标是通过重新设计动脉测量和相关的数据处理来解决这个问题。将在体外和体内验证由此完成的脑灌注定量MRI测量方法。该项目的成功将首次实现定量灌注。

Assessment of cerebral perfusion is a recognised diagnostic tool in acute stroke, chronic cerebral ischemia attributed to arterial stenosis. Perfusion measurement using magnetic resonance imaging (MRI) demonstrates a superior potential among other methods concerning its diagnostic value by multiple imaging modalities and missing irradiation exposure. The MRI measurement of perfusion is based on a comparison of the passage of a tracer through brain tissue and its feeding artery. This method was developed at a time when the physics of underlying processes was not fully understood. This manifests itself in poorly reliable quantitative data that hinders diagnostic prognosis, control of therapy, inter- and intra-subject comparisons. We recently proposed a solution to the problem related to the tracer passage through the tissue employing the recent advances in the understanding of the underlying physics. The remaining problem concerning the measurement of the tracer passage through the feeding artery still persists despite strong efforts of the research community to find a solution. With this proposal we aim at solving this problem by redesigning the arterial measurement and the associated data processing. The thereby completed method for quantitative MRI measurements of cerebral perfusion will be verified in vitro and in vivo. The success of this project would enable the quantitative perfusion for the first time.