A study on a new vitamin E

我们从鲑鱼卵的亲脂部分中分离到一种新的α-生育单烯酚，它在无处不在的α-生育酚(α-Toc)的植酸链末端具有异常的亚甲基不饱和。在北太平洋(北海道海)冷水环境中捕获的浮游植物和浮游动物样本中，这种海洋衍生生育酚(MDT)与α-Toc的比例很高，我们的发现表明，不含MDT的养殖鲑鱼几乎没有MDT，这表明MDT是从冷水食物链中自然产生的浮游植物中营养获得的。我们在体外实验中发现MDT和α-ToC的抗氧化活性几乎没有差异，但在0ﾟC时，MDT在鱼油中的抗氧化活性更高。同样，我们发现MDT在粘性的、含胆固醇的脂膜中比在不含胆固醇的脂质体中表现得更好。我们的结果表明，MDT可能在冷水海洋生物的抗氧化功能中提供了重要的生理优势。

We have isolated a new a-tocomonoenol from the lipophilic fraction of salmon eggs which has an unusual methylene unsatutation at the terminal phytyl chain of ubiquitous alpha-tocopherol (alpha-Toc). This marine-derived tocopherol (MDT) was found at high ratio with alpha-Toc in phytoplankton and zooplankton samples captured in the cold-water environment of the North Pacific Ocean (Hokkaido Sea) and our finding that aquaculutured salmon fed with a MDT-free diet had little MDT suggest that MDT is trophically acquired from natural phytoplankton production in the cold-water food-chain. We found little difference in the antioxidant activity between MDT and alpha-Toc in vitro, but observed higher activity for MDT in fish oil at 0ﾟC.Similarly, we found that MDT performed better than alpha-Toc in viscous, cholesterol-incorporated liposomal membranes than in cholestrol-free liposome. Our results suggest that MDT may provide an important physiological advantage in antioxidant functions of cold-water marine organisms.