Life history, serotonin transporter genotype and anxiety-like behaviour: testing the "coping-with-challenge hypothesis" (A01)

该项目旨在调查遗传因素和一生经历之间的相互作用，以形成焦虑样表型。在三个连续的实验中，“应对挑战假设”将被测试，假设：应对逆境对生活早期积极经历的焦虑状况有有益的影响。为此，将使用行为生物学、认知心理学和分子遗传学的方法研究一种已建立的焦虑模型-不同血清素转运蛋白基因型的小鼠。

The project aims at investigating the interplay between genetic factors and experiences throughout lifetime in shaping the anxiety-like phenotype. In three consecutive experiments, the "coping-with-challenge hypothesis" will be tested that posits: Coping with adversity has beneficial effects on the anxious profile when following positive experiences earlier in life. For this purpose an established model of anxiety - mice varying in serotonin transporter genotype - will be studied using methods from behavioural biology, cognitive psychology and molecular genetics.