Biogenic amines, malaria and manipulation of mosquito physiology and behavior.
生物胺、疟疾以及蚊子生理和行为的控制。
基本信息
- 批准号:10515589
- 负责人:
- 金额:$ 55.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-08 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AbdomenAddressAedesAnopheles GenusBehaviorBehavioralBiogenic Amine ReceptorsBiogenic AminesBiological AssayBiologyBiteBloodBrainBrain regionCerebrumClinicalClutch SizeCollaborationsComaCulicidaeDangerousnessDataDevelopmentDiseaseEnzymesFalciparum MalariaFeeding behaviorsFertilityFutureGenesGoalsHistamineHistamine ReceptorHistamine ReleaseHumanHyperphenylalaninaemiasInfectionIngestionInsectaInterruptionInterventionInvestmentsKnowledgeLiver diseasesLongevityMalariaMapsMediatingMetabolismMidgutModelingMusNeuromodulatorNeuronsParasite ControlParasitesParasitic infectionPathologyPatternPharmaceutical PreparationsPhysiologicalPhysiologyPlasmaPlasmodium bergheiPlasmodium falciparumPlasmodium yoeliiPopulationPublishingReportingReproductionResistanceRetinaRiskSensorySerotoninSignal TransductionSporozoitesSymptomsTranscriptTryptophanTyrosineVectorial capacityVisualantagonistbasefeedinghuman diseaseimprovedinnovationinsulin-like peptidelife historymathematical modelmosquito-borneneurophysiologyneurotransmissionnovelolfactory stimulusreceptorreceptor expressionreproductiveresponseserotonin receptorsmall moleculesuccesstraittransmission processtreatment effectvector mosquitovector transmissionvisual stimulus
项目摘要
Project Summary/Abstract
Severe malaria induces changes in circulating blood levels of the biogenic amines histamine and serotonin
(5-hydroxytryptamine, 5-HT) and these changes are associated with human disease pathology. Histamine and
5-HT are also important neuromodulators in insects, including mosquitoes. Our overarching hypothesis is
that histamine and 5-HT, ingested in blood by feeding mosquitoes, signal through anopheline biogenic amine
receptors and alter endogenous biogenic amine levels, life history traits, behavior and mosquito infection
success to amplify malaria parasite transmission. These studies are innovative in that they connect novel
mosquito biology to clinical observations in malaria, they focus on mosquito ingestion of biogenic amines at
physiological levels detected in blood and they will define previously unexplored anopheline gut-brain axes for
histaminergic and serotonergic signaling. We will address our overarching hypothesis with three Specific Aims.
In Aim 1, we will define and model the scope of effects of ingested histamine and 5-HT, alone and in
combination at concentrations that reflect malaria-associated and healthy blood levels, on An. stephensi
infection success with Plasmodium falciparum and with the mouse parasite Plasmodium yoelii yoelii 17XNL.
We will also examine the effects of these treatments on the tendency to take a second bloodmeal,
thermotolerance, fecundity, clutch size and lifespan. In Aim 2, we will use antennal and retinal recordings and
behavioral bioassays to define the effects of ingested histamine and 5-HT, alone and in combination, on visual
and olfactory physiology in An. stephensi. In Aim 3, we will quantify endogenous histamine and 5-HT in An.
stephensi and map associated histaminergic and serotonergic gut-to-brain signaling networks. We will also
identify and model effects of ingested biogenic amines on levels of endogenous biogenic amines and use
histamine and 5-HT receptor antagonists to interrupt signaling control of malaria parasite infection, tendency to
take a second bloodmeal and reproduction in An. stephensi. With completion of these studies, we will establish
that biogenic amine concentrations associated with severe malaria and ingested by feeding mosquitoes can
alter mosquito physiology and biology in patterns that would be predicted to favor parasite transmission. Such
knowledge can be used in the future to connect transmission control to clinical interventions (e.g., to reduce
elevated histamine and reverse declines in 5-HT to mitigate human malarial disease) and for future
development of novel lures to manipulate biogenic amine signaling in vector mosquitoes.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Shirley Luckhart其他文献
Shirley Luckhart的其他文献
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{{ truncateString('Shirley Luckhart', 18)}}的其他基金
How to starve a parasite: Manipulating CoA biosynthesis to control Plasmodium development in the mosquito
如何让寄生虫挨饿:操纵 CoA 生物合成来控制蚊子体内疟原虫的发育
- 批准号:
10656980 - 财政年份:2023
- 资助金额:
$ 55.68万 - 项目类别:
Biogenic amines, malaria and manipulation of mosquito physiology and behavior.
生物胺、疟疾以及蚊子生理和行为的控制。
- 批准号:
10679076 - 财政年份:2022
- 资助金额:
$ 55.68万 - 项目类别:
Midgut mitochondrial function as a driver of resistance and fitness in mosquitoes
中肠线粒体功能作为蚊子抵抗力和健康的驱动因素
- 批准号:
9752692 - 财政年份:2018
- 资助金额:
$ 55.68万 - 项目类别:
Malaria and allergic inflammatory changes to the gut barrier
疟疾和过敏性炎症对肠道屏障的改变
- 批准号:
10170213 - 财政年份:2018
- 资助金额:
$ 55.68万 - 项目类别:
Harnessing midgut mitochondrial dynamics to enhance Anopheline mosquito fitness
利用中肠线粒体动力学增强按蚊的适应性
- 批准号:
8881816 - 财政年份:2014
- 资助金额:
$ 55.68万 - 项目类别:
Fluidigm BioMark HD MX/HX Real-Time PCR System
Fluidigm BioMark HD MX/HX 实时 PCR 系统
- 批准号:
8446862 - 财政年份:2013
- 资助金额:
$ 55.68万 - 项目类别:
The Burden of Malaria Transmission due to Asymptomatic HIV Co-Infection
无症状艾滋病毒合并感染导致疟疾传播的负担
- 批准号:
8549951 - 财政年份:2012
- 资助金额:
$ 55.68万 - 项目类别:
The Burden of Malaria Transmission due to Asymptomatic HIV Co-Infection
无症状艾滋病毒合并感染导致疟疾传播的负担
- 批准号:
8711275 - 财政年份:2012
- 资助金额:
$ 55.68万 - 项目类别:
The Burden of Malaria Transmission due to Asymptomatic HIV Co-Infection
无症状艾滋病毒合并感染导致疟疾传播的负担
- 批准号:
8466428 - 财政年份:2012
- 资助金额:
$ 55.68万 - 项目类别:
EFFECTS OF MALARIA ON PARASITE INFECTION ON INTESTINAL RESPONSE
疟疾寄生虫感染对肠道反应的影响
- 批准号:
8357364 - 财政年份:2011
- 资助金额:
$ 55.68万 - 项目类别:
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