Natural Killer Cell Activity and Other Immunologic Function in the Normal Elderly : an Assodiation with Infection

We examined natural killer （NK） cell activity （lytic units， LU） and lymphocyte subsets （CD3+， CD4+， CD8+， CD25+， CD56+， CD3+HLA·DR+， CD3+CD56+ and NK [CD3-CD56 +] cells） in the immunologically normal elderly。《免疫学本体研究入学标准》（Mech Ageing Dev 1984; 28： 47-55）、世界卫生组织2或3级业绩状况和知情同意书。LU中的一个正常主题是一致地确定每一个NK细胞的活动，以提高该报告的可靠性。进一步，这个主题的LU被定义为100，被测试主题的LU的相对潜力（更正的LU， CLU）被计算。108个主题（83名女性; 81岁[SD 8，范围63-99]）已确定我们研究了与以下时期内任何已知参数有关的感染性剧集。低CLU，年龄超过75岁，性能状况为3，血清专辑价值小于3.5克/升，与感染的发展相关。多功能逻辑回归分析显示，较低的NK细胞活动是感染发展的独立预测器。

We examined natural killer (NK) cell activity (lytic units, LU) and lymphocyte subsets (CD3+, CD4+, CD8+, CD25+, CD56+, CD3+HLA・DR+, CD3+CD56+ and NK [CD3-CD56+] cells) in the immunologically normal elderly. Criteria for selection were the admission criteria for immunologerontological studies (Mech Ageing Dev 1984; 28: 47-55), a performance status of World Health Organization grade 2 or 3, and informed consent. The LU of one normal subject was determined concurrently in every NK cell activity assay to ascertain the reliability of the assays. Further, the LU of this subject was defined as 100, and the relative potency of LU of the examined subjects (corrected LU, CLU) was calculated. CLU of 108 subjects (83 females; 81 yeards old [SD 8, range 63-99]) was determined. We examined whether any of the predetermined parameters related to infectious episodes during the follow-up period. A lowr CLU, age over 75 years, performance status of 3, and serum albumin value less tha 3.5 g/dl correlated with the development of infection. Multivatiate logistic regression analysis showed that a lower NK cell activity was an independent predictor for the development of infection.